As @ghdprentice says - "Proper toe-in is definitely one of the critical basics of speaker placement", which I am in complete agreement. But one thing which no-one has mentioned; and that's to look at what YOUR speaker maker recommends, and start there. I use Mag 1.7i's and they reco that the tweeter should be closer to you (when tweets placed on inner edge) = toe in. Each speaker type has massively different vertical and polar response plots, so one cannot say that toe in/out for speakers is good/bad/right/wrong. It depends entirely on the speaker and the room. My old Apogee Stage used very little toe in, but these Mags require quite a lot. And TINY changes make a large and noticeable difference, and staying with panels, the tilt of the speaker; Apogee even supply a plumb line to get this right. And panel distance to listener MUST be the same - I use a laser measure, and just moving one speaker 10mm (3/8" to you guys) forward/back makes a BIG difference to the focus of the sound stage.
And, @ortodox - that is completely wrong. Horns require toe in/out/none adjustment too, as acman3 also says - I KNOW, from personal experience.
As for @incorrigable - What a load of balony (I couldn't think of anything less insultng to say, rather than what I wanted to say!) - BO**OCKS. Which can also be applied to your 2nd paragraph, more so in fact! WtF has Power got to do with anything here? NOTHING! And; "If toe makes you post here make your next speakers something that radiate nice and wide" - what ARE you on about?? Stop taking whatever you're on!