After experiencing the Micca 14-gauge speaker cables ($25, recommended by Steve Huff) and the Belden 5T00UP 10-gauge cables (DIY for $50; BlueJean for $100), I strongly believe that speaker cables can make a significant difference, primarily due to their RCI (resistance, capacitance, and inductance) properties and the geometry of their construction. However, you don't need to spend a fortune to get decent cables that work well with your system.
Although I belong to a different camp, I do agree with Jasonbourne71 that blind testing is essential to achieving an objective assessment of speaker cables—or any cables, for that matter.