What contributes most to a change in how an amplifier sounds?

Application 

In short, speakers and listening environment. 

IMHO amplifier is more important than speakers and sources. 

Reminds me a bit of the old story where organs of the body are having a fight over who was most important.  Can’t remember what the plot twist was — something like the little toe saving the day.

But the moral was the organs make up a team, all of which is “most important” depending on what is going on.

@davetheoilguy    when you go into cardiac arrest, I think the answer to the above will be clearer.

@immatthewj 

When you die a horrible painful death from liver cancer, screaming for relief to come, think the answer to the above will be clearer.

Seriously, what a horrid thing to say.  Grow up and get a life.