Then there's a 2-way pair with a sub that can cure or complicate where and how driven and the dispersal of said.....a 3-way with sub would seem to live better in a larger space....
It can as well to consider the thoughts to the size of the various drivers applied, 2 or 3 x sub size.....
...an that's why I like a good equalizer, even if the speakers have on-board adjustments for the x-overs...
My approach, a IMH....*s*