Typically the right interconnect or cable will have make a noticeable and important difference. But once in a while it can make a huge difference. I remember my first digital cable... which I was absolutely sure could not possibly affect the sound. I plugged in the high end aftermarket interconnect between my transport and DAC... late 80’s. My jaw dropped... literally. It was as if someone had taken the components out and brought in new ones of much higher sound quality. The system went from thin and tinny to robust with a midrange and much better bass. I was just shocked, completely changed the system.
Another time probably in the 90’s I had ribbon speakers and all solid state gear... not contemporary top of the line... but a Threshold S500 amp, T2 Threshold preamp. I got Transparent speaker cables. The system sounded terrible. So much treble...and again thin... without midrange. I paid a lot for the Transparent. I got a set of Cardas Gold Reference speaker cables... probably the warmest thing on the market. OMG, suddenly it sounded like music, there was a midrange! good bass. The combination of ribbon speakers and that old solid state stuff with really transparent interconnects was just a bad combo. The Cardas balanced the sound out.
Funny, I now run virtually all Transparent cables and interconnects... because my components sound like they should... full bodied and musical, natural with great bass... I don’t want anything in the way. That is exactly what Transparent are.