Not an easy question to answer in a vacuum, but the premise of your question seems to be that you have heard these hypothetical components and to your ears you have the budget to buy one that sounds better and is built better than the cheaper one. Since you have the budget, I'd go for the better built, better sounding gear. You are going to be better satisfied and more likely to keep it in your system.
For me, this would be particularly true if you're talking about speakers. I think speakers make the most difference and the range of performance across speakers is greater than than with electronics, to my ears. So, I'd get the speakers that most suit you for the money you have to spend.