I have owned many speakers over the years. There were a few that did not benefit from subs, but they were also cheap, off the shelf, great for dorm parties, speakers.
With quality speakers I believe most benefit. My full range Acoustat 1+1 speakers are really wonderful on their own with jazz, solo, and small ensemble performances. However, with orchestral, pop, or rock they are just OK. Add a pair of subs (originally Vandersteen, but now Rythmik) and the details explode. It seems to me that hard to drive speakers really open up with subs and become more musical when the bass duties are removed. I use an SPL Crossover (active) to limit the signal to the mains.
I have heard some amazing full range speakers that do not have subs. Surprisingly, many of the owners of these great speakers frequently add subs and are amazed at how much better they are. Subs need to be properly dialed in to make a difference (in my opinion both low and high pass crossovers provide the best benefits).
Ultimately though, the end user has the final say. We are really here just to enjoy the music... I hope.