Hi Hickory,
Nsgarch mentioned concentrating on the change in bass response and you concentrate on the high end. Both extremes are critical. Because I expect a good MC cartridge to deliver an open and airy top end, I am particularly concerned with loading that maintains enough top end response while avoiding excessive brightness and sibilance. I tend to, like you, concentrate a bit more on the change to top end response.
Just to clarify things, "high loading" is where you use a lower value resistor. Whether you are using one resistor or several values, these resistors are in parallel with the signal from the cartridge and act as a voltage divider -- a high value resistor mean LESS current is flowing through that path and more is flowing along the original path. Hence, a very high value, like 47k or 100k acts almost as if that path is not existing at all.
Another thing worth mentioning is that changing the loading of the cartridge has a similar effect on tonal balance as changing VTA of the cartridge. A high VTA tends to sound somewhat like lower amounts of loading (i.e., a high value of loading resistor). So, to some extent, you can juggle small changes in VTA with changes in loading to get an optimum combination. This adds to the complications, but, it also adds to the possibilities that an ideal combination can be found. If you have a tube phonostage, you can throw into that mix changes in brand/model of tube to further complicate things.