I'm taking a poll...

I would have to say B, as on my VPI I adjust for what is TO ME the proper balance between treble and bass. I knock no one for adjusting VTA (and VTF) for different thicknesses of LP's nor for doing same for every LP. I'm just not that anal. Also, the amount of adjusting I do is inversely proportional to the amount of zinfandel or single malt I have imbibed.--Mrmitch

B. But I do A so I can live an easy life.

I go for A, life is too short to adjust VTA with each record, particularly if VTA is not adjustable on the fly. The extra factor to consider is the cartridge. I think there is no doubt VTA affects the sound, in general front down accentuates treble, back down the base. I know it is'nt as simple as that. For my last Koetsu Rosewood signature, it sounded better front down slightly, with my current Zyx Airy 3, dead level.
I do'nt think one should ignore the potential for "tuning " the sound to your preference.

How do we measure 2 degrees on something like a stylus? A profile projector. I have one at work, costs 40k, does anybody else own one?

Atlasiris,
You can look at the stylus (under magnification) from the side as it sits on a first surface mirror and adjust it for zero degrees easily. The stylus and its reflection will appear like a perfect "X". Then do a calculation that tells you how high to raise the arm to put the stylus at a 2 degree angle.

and a tonearm that has on-the-fly dial-in height (The arm base height "dial" is marked in millimeter increments), I can change cartridges faster than I can change a record and with absolute repeatable results. That said, since the wands are of differing mass, I can also hear each cartridge in an optimized environment.

I love each cartridge I use, but I must admit that depending upon the music, I do have a preference for one over the other. This is why I have had this set-up for nearly 30 years.

Cheers!