Tube failure -- what would happen in worst case?


How do you determine when a tube is to be replaced?
Can a tube ever glow bright red and blow up?
If it does, would it damage the amp itself as well as other components including the speakers?
128x128ihcho
As has been said, a fire is the worst thing that can happen.

Apart from that, I've seen amps take a transformer (power or output) out. That's a repair you don't want to get into.
Thanks for all.
I did not bother to bias my tube amp, and I am selling one (Chinese made) and get an amp with auto bias feature (BAT vk60).
Any way, is this a good reference for biasing?
http://www.aikenamps.com/Biasing.html
Any of you have other source?
I guess I was lazy and ignorant. I assumed that a new tube amp was factory biased and I should not fiddle with it, and also I did not want to damage my amp by screwing up. Now I feel like I need to know more about biasing.