You will certainly get a more rounded, less edgy sound with a non-stone Koetsu (i.e., not the jades, or coralstone, etc). But, that comes with some woolly quality and overly prominent (and slow) upper bass.
I like Allaert cartridges for a smoother and refined sound while not giving up too much in dynamics.
Syntax raised a good point about cartridge arm compatibility. The Lyra cartridges have metal bodies designed to convey vibrational energy from the cartridge body into the arm for the arm to dampen/dissipate. The arm must be well designed for that task to get the most out of those cartridges. In some threads, Jonathan Carr, the designer of Lyra cartridges mentions some arms he considered well up to the task (sorry I cannot remember which arms are mentioned).