Help with fatiguing sound in my PC system

I am running a Asus notebook running Windows 7 64bit and J Rivers 17. The usb output from the notebook goes to a Musical Fidelity V-Link via a Wireworld Starlight usb cable and a Wireworld Starlight coax cable from the V-Link to a Wyred Dac 1. The sound is extremely detailed, NON FATIGUEING, and musical. All my hi-rez files sound incredible. All my files are ripped into flac and output the player in waspapi mode.

First thing I would do is ditch iTunes and try the J Rivers 17 Media Player. You can use it free for 30 days and then decide if you like it. It blows away iTunes by a wide margin.

Here's a summary of my experience:

- A system with a murky source may not exhibit fatigue, but once you give it a very revealing, resolving signal, it may become quite fatiguing.
- Improving the quality of the source, like what the Off Ramp 5 is able to do, makes a difference. But to me, it makes things sound better rather thank make things bearable. As always, your mileage may vary.
- It's not just speakers, it's also the amplifier and how the speakers and the amplifiers work together.
- Synergy is important. And certain components will bring a certain character to your system. For example, a Leben sounds warm, lush and beautiful. Never heard anyone describe a Leben or a Shindo as fatiguing.
- If you're going to buy a USB SPDIF converter, the Off Ramp is markedly better than the Audiophilleo.
- The hobby gets more expensive when you want ultra resolving, natural, musical, non-fatiguing, full of body, and transparent all rolled into one.

stereo 5, agree that iTunes is terrible by itself. This is why I purchased Jplay, tried it with both Jriver and Foobar, and could not hear a difference compared to iTunes with Jplay, so I stuck with iTunes as my software of choice. I have been managing an iTunes library since the iPod 5th gen came out, so I'm used to and like the interface. Jplay gives bit perfect output using kernel streaming and loads the tracks into RAM, the HD is never touched for playback, and it sounds really good.
First reflection points and maybe a bit of dampening overhead would be the only places I'd put absorption. Thanks for the mirror trick, Steve. I have a window on one side with a double cell fabric blind, might add drapes there.
And yeah, the off ramp is better than the audiophilleo, I'm sure, But it's also got a much higher entry level price point ($1200?).. I don't want to totally out pace the rest of my system, once the interface is upgraded, I'll have some more work to do to bring the rest of the system up. I never really thought i would take the Pc audio plunge, but the convenience and fun of the iPad interface made it irresistible, and there really hasn't been that much tinkering.

I'll be honest. There is no single magic bullet in my experience for listening fatigue. I have found all of these to matter for digital music

1. use PC source with asynch USB (check, you are doing that)
2. use a quality DAC (check, you are doing that)
3. use quality interconnects (check you are doing that)
4. use a quality PC media player (no, you are not doing that... consider JRiver or Foobar2000. At lower processor speeds Foobar is better but with the latest generation of CPU's JRiver is as good or better and much more user friendly. Itunes is pleasant but shallow in musical detail)

At this point your PC audio out shouldn't be the source of fatigue. Look to the rest of the system. Consider a Rogue Cronus or a Prima Luna integrated tube amp as a safe choice to bypass solid state issues that commonly cause listening fatigue. Leave speakers for last.. buying better speakers at this point will likely expose more to hate.

Davide256 - I use the Jplay plugin with iTunes. This plugin loads the tracks into RAM, then plays them back from memory without ever hitting the HD. It uses kernel streaming or WASAPI, and has several other adjustments for memory management, also features a bit-perfect volume control in 6dB increments. Sound improvement over stock iTunes is astounding. I tried this plugin with Foobar and JRiver trial software and could not hear a significant difference, so I stuck with itunes as the interface. That might change later, Jplay and iTunes don't play so nice together.
The immediate, in-reach upgrade is a converter that has dual clocks, so I am not synthesizing a 48kHz stream from 44.1kHz data. If that does not improve things, you're right, I have to consider going to a high-quality integrated, upgrading speakers, etc.