Where do I make the long run IC or speaker cable?

Ditto Elizabeth

I have heard just the opposite......short interconnects with long speaker runs.

Chuck

I would do the inverse.Short distance on low-level signal and longer where you have the added current/voltage,past the power amp.There has been numerous discussions on the benefit to damping with speaker cables of at least 6.5' and longer.Do the experiment and report your findings.I'm sure the cable manufacturer will be able to add their perspective.

I vote for short speaker cable, long interconnect.

As Tpsonic mentions though, you could check with a cable manufacturer, or even an preamp/amp manufacturer for that matter.