Are there any constants in speaker wire designs?

Kijanki - "I can make argument as well, that if you want to believe that top cables don't sound any better than cheap lamp cord - they won't (negative placebo effect)."

While I'm someone skeptical about the real sound difference in speaker wires I'll admit to hearing a difference in other audio related things that I wasn't expecting it. I think I'm fairly objective in the sense that I'll admit hearing something when it's not expected. An example was the difference in the sound of a CD player with the addition of Nordost Sort Kones. I did point out that even thought I could hear the difference on Focal Scala speakers and associated hi end gear I would have to guess if the Sort Kones were installed if I left the store and came back later. There were others that considered the difference to be more significant that I did. I'm starting to look for an excuse to demo some different cables and see for myself, but I'm not really to commit to a financial investment quite yet (i.e. 5% down at the Cable Company).

Should I be able to hear a difference between my Monster wires and say a large gage cable from Home Depot? What should I use to do a cheap in home comparison to verify theory for myself?

Mcelio - AFAIK Nordost cables offer specific "house sound". Let just say that if you're looking to add warmth to the sound or suppress sibilance Nordost isn't the one. On the opposite side is Cardas that is warm sounding but does not have transparency of Nordost. Try both if you hear the difference. My Monster speaker wires (thick stranded in clear insulation) were suppressing treble - Nordost should add treble and extension.

Can you borrow cables from the the local audio store for a few days - just to see if you can hear the difference? Ideal would be to borrow completely different families like Cardas and Nordost.

Should I be able to hear a difference between my Monster wires and say a large gage cable from Home Depot? What should I use to do a cheap in home comparison to verify theory for myself?

Whether or not you believe you hear a difference is a different matter than if there really is a discernible difference. (What a mouthful.) Objectively, between these two equally good choices, there won't be a measurable difference. You might consider some high quality spades or banana plugs for a tight, secure connection, but that's about it.

Wire measurables make a difference. Too much capacitance? Too much resistance? Current source amp? Voltage source amp?
skin effect? Doesn't seem to be a player. Copper oxide? If it's a semiconductor it also has properties of a resistor. How THICK is this oxide? How much voltage does it take to bridge this oxide? (dielectric constant?)

Sound basic design will result in proper cables. All else would appear to be window dressing or pseudoscientific wish fulfillment.

Kijanki, what Nordost cable line you are refering to? I know very well Nordost Heimdal IC and Nordost Frey IC, & Nordost middle line SC I can honestly say that your adjectives does not belong to Nordost.

Heimdal, for instance, will give lots of warmth, and bloom to vocals, while Frey blends warmth, transparency, details, and complete sound from top to bottom, while keeping everything mixed with musicality.

Before entering Nordost, i also expected fast, transparent, clinical sound (from Medical equipment company!) but I found the sound I was really searching for , and really was not expecting.

ps.: sibilance and harsh is gone once cables are really broken in.