I think "Snow" does have an improvement. I've compared Macs/iTunes with "Tiger" vs. "Snow", and Snow tends to consistently have better sound quality. It's usually subtle, but on some systems, in can be obvious.
As for 64 bit, I'm undecided. I've heard some subtle difference with some systems and others have confirmed similar experience, but I can't come to a conclusion.
The only thing that I do feel comfortable recommending is at least 4GB of RAM and an SSD (solid state drive). These options improve the performance and responsiveness on the Mac, and (I feel) improve the sound quality. There is no evidence to fully support that an SSD drive should effect sound quality, but after years of listening to Macs with SSDs, I think they have an advantage.
As for 64 bit, I'm undecided. I've heard some subtle difference with some systems and others have confirmed similar experience, but I can't come to a conclusion.
The only thing that I do feel comfortable recommending is at least 4GB of RAM and an SSD (solid state drive). These options improve the performance and responsiveness on the Mac, and (I feel) improve the sound quality. There is no evidence to fully support that an SSD drive should effect sound quality, but after years of listening to Macs with SSDs, I think they have an advantage.