depends on various things and mainly on:
(1) the effect on your speakers (one size does NOT fit all)
(2) how far up the food chain are the speaker cables selected. The better the cable, the less favouritism toward bi-wiring. For example, on the CHORD website, CHORD is migrating away from 2 to 4 bi-wiring in favour of single runs with jumpers:
Bye Bye Bi-wire?
We have taken the decision to discontinue our range of dedicated bi-wire cables. The reason being, that in the vast majority of cases we believe that the best, and more importantly the most musical performance is obtained by using the best quality single wire speaker cable that falls within your budget, rather than a bi-wire cable of the same cost.
see website at www.chord.co.uk/products.php?pg=242