You can invert the polarity of one channel and measure accross the positive leeds at the speaker, with a mono source you will then be measutring the difference between channels. Then with different cables on each channel, you will be measuring only the difference caused by the cable and since the differences will be very low you can add amplification to bring the signal above the noise floor of your sound card. An intersting variation of this descrived by Hafler allows you to listen to the difference signal directly.