Impossible to generalize, but I would definitely always at least try balanced connection on any gear that is *truly balanced* interally. On gear that is not, but provides for balanced connection anyway, experiment at your option - it's really the only way to know what you'll get.
BTW Audioengr, I take it from your comment about male/female connectors and not being able to hook up things 'backwards' that you are down with the theory of wire directionality - or were you just referring to not being able to accidentally plug an input into an input or an output into an output?
BTW Audioengr, I take it from your comment about male/female connectors and not being able to hook up things 'backwards' that you are down with the theory of wire directionality - or were you just referring to not being able to accidentally plug an input into an input or an output into an output?