Regarding DACs, I use a firewire dAC, which is another vote in favor of Macs (although some Windows computers have firewire outputs, such as Sony VAIO).
My only experience with a non asynchronous USB is via the aforementioned
Marantz NA 7004. I would like to try Empirical Audio Off Ramp and Musical Fidelity V_Link but I have no experience as yet with these products. If your budget will allow for the Weiss DAC I would strongly consider pairing that with
a firewire output PC.
I've also used a MacMini similar to the way that Timrhu has and was very pleased, and I second his comments about the space savings offered by a MacMini.
My only experience with a non asynchronous USB is via the aforementioned
Marantz NA 7004. I would like to try Empirical Audio Off Ramp and Musical Fidelity V_Link but I have no experience as yet with these products. If your budget will allow for the Weiss DAC I would strongly consider pairing that with
a firewire output PC.
I've also used a MacMini similar to the way that Timrhu has and was very pleased, and I second his comments about the space savings offered by a MacMini.