I've owned the Paradigm 100'sv2 as well as the PSB Goldi's and although my equipment has changed since I had both I have to say that the PSB Gold's mid range is wonderful, especially for the price. The bottom end seemed a more full on the PSB as opposed to the paradigm. However, the Paradigm had a slightly tighter bass kick than the PSB and really more of a neutral sound to offer. I used the Paradigms with a solid state system and the PSB goldi's with the same solid state system as well as my now tubed based system. As far as using them in a room your size, how much you get out of either of these speakers will depend on your sitting position and the acoustics of the room. Both speakers IMO should be able to handle that much space and if not you're going to have to kick out a lot of extra bucks to find a speaker that can.
My humble system:
PSB Goldi's on 2" concrete slabs
Bryston 3Bst - 2-channel
Sonic Frontiers Line -1
Acurus ACD-11 / modified MSB Link DAC3
Harmonic Technology Truth Links ITC's
DH Labs Q-10 Bi-wired speaker cable
Vibrapods
My humble system:
PSB Goldi's on 2" concrete slabs
Bryston 3Bst - 2-channel
Sonic Frontiers Line -1
Acurus ACD-11 / modified MSB Link DAC3
Harmonic Technology Truth Links ITC's
DH Labs Q-10 Bi-wired speaker cable
Vibrapods