I'd suggest a used pair of original Quad ESL's (the "57's") as among the most non-fatiguing speakers at any price, and if not Quads then Maggies.
Boxiness is a subtle but persistent source of listening fatigue, and it's fairly expensive to build boxes that don't sound like boxes. So in your price range, if non-fatiguing is the primary criteria, I enthusiastically recommend dipoles such as the Quads or Maggies.
The Maggies are more much forgiving of listening position, while the Quads are a bit more forgiving of speaker position. The Quads like low-power (usually tubes), and the Maggies like fairly high power. The Maggies don't really come to life at low volume levels like the Quads do.
On the other hand, if you gotta have boxes, the Vandies would be a good choice.