Well, this is becoming a good thread with lots of relevant commentary. I have a few clarifying remarks I'd like to add:
1. I did not mean in my opening post to sound disparaging about the 2Ce/2Wq combo. Before owning 3A Sig's, I owned the 2Ci and then the 2Ce, and I think it is an excellent speaker offering very high value. IMO, however, the 2Ce is some distance from the Model 5 in performance, whereas the 3A Sig is much closer.
2. Someone above commented that the 3A's are much bigger than the 2Ce's. Depends on what aspect of size you mean: the 3A/3A Sig's are about 8" taller than the 2Ce, but the width and depth of the two speakers are identical (16" wide, 10" deep). Put differently, both speakers have the same footprint, but the 3A is taller. The extra volume of the 3A/3A Sig speaker cabinet contributes to its slightly lower frequency response, but the main difference between the 2Ce and the 3A series is attributable to the 3A series having better quality drivers and crossover.
3. Marakanetz comments that the Model 5 has a more powerful built-in amp than the 2Wq sub: 400 watts vs. 300 watts. As a practical matter, this power difference is negligible, amounting only to about 1db difference in power output. The smallest discernable increase in volume for most people is 3db, and to achieve a 3db gain you must double the power of the amp (i.e., go from 300 watts to 600 watts).
The 2Wq sub is capable of response down to about 18 Hz, whereas the subwoofer in the Model 5 may get down another 2 Hz or so lower. As a practical matter, this is also largely irrelevant, since your listening room will almost certainly restrict output below 22-24 Hz. The lowest frequency reproduced by any musical instrument, the pedal organ, is about 16 Hz, but there are not more than a handful of recordings with frequencies that low. The LFE in home theater is also restricted below 25 Hz. Hence, it does not make much sense to obsess about trying to reproduce frequencies much below 22-24 Hz unless you have a really large, really GOOD listening room.
The chief virtue of the equalizer built into the Model 5 is to provide a more uniform frequency balance in the lower 2 octaves (20-40 Hz, and 40-80 Hz), not to enhance response below 20 Hz. It's 11-band equalizer allows the user to discretely adjust for dips and peaks in the lower 2 octaves, where there can be significant response anomalies from one room to another.
If you read the posts made by owners of the Model 5, you will generally find that they most appreciate the balance and transient response of the subwoofer. The proprietary subwoofer in the Model 5 actually uses two 12" cones which oppose each other and operate in push-pull fashion, and are driven by an enormous magnet assembly. The 2Wq sub uses three 8" drivers which have roughly the surface area of a single 14" driver, which is substantially less than the two 12" drivers in the Model 5.
To wrap up this rather rambling note, I don't mean in any way to discourage you from starting your system with the 2Ce/2Wq combo. However, if your budget will allow, get a pair of 2Wq subs, since they provide much better system performance than a single sub. Infact, Richard Vandersteen really designed the 2Wq to be used in stereo pairs.
Last, if your budget allows, get a pair of used 3A's -- there is a pair listed here on Audiogon for $1500. They will give you better performance than the 2Ce, and they can be upgraded to the 3A Sig's at a later time for relatively little.
Hope all this helps and isn't overkill. Good listening!