Each room/setup/layout/gear selection is different, and calls for different variables to be adressed for best "balance". It's all a balancing act, and all things must be considered together for the overall effect. You simply can't just take a blanketed formula, like an "equilateral triangle setup", or 10/11 whatever, and assume good restults! It's all very situational.
You must tinker and try things.
First thing I always do is FIGURE OUT THE BEST SEATING POSSITION(S)! I find the location(s) where I'm going to get potentially the best frequency response and foundation from with wich to anchor my EARS! If I can get smoothest response from there, I go there...all things considered. Obiously there's compromises often...but then you adjust from there too from the speaker and acoustic treatment end!
Anyway, I then am going to find the coresponding speaker locations up front that offer the best, smoothest, most even frequency response in relation to the seating position(s)! If from the seating position(s) I can get the speakers to yield the flattest and most even response, I've got a solid foundation for accurate, dynamic, natural sound(not boomy, lean, peaky, inaccurate pressentations). If I can't get that, I'll consider EQing the bass woofers if possible to deal with any serious challenges. Yet, I'll most always get the locations for both the speakers and seats working together to give flat response...CRITICAL!
You then must balance those "ideal" or "best" location choices with the soundstage and imaging parameters.(i.e, triangle, width, depth, whatever). If my location considerations for speakers/seats let me chose spots that will yield a setup that has the proper perspective and geometry for a sharp, coherent, solid image, with a good soundtage(width, depth, height, perspective, etc), then you're there!!! Then you need to consdier "toe-in" for tonality and focus fine tuning, as well as "aim" or "angle" of speakers towards listening possition", etc.
After that, I'm consdering all the acoustical needs, in relation to the set up(speakers and listening possitios). I deal with overall reverb(must study this part), and mostly treating corners for bass/imaging, and FIRST ORDER REFLECTION POINTS PRIMARILY! Once you balance out this part for best absorption/diffusion considerations, depending on room needs(long wall setups can get away with less of this often, while short wall setups usually require much more strongly considered acoustical add on's for good sound!!!!...due to signal reflection/boundary interaction to your ears!...mixing the rooms reflections with original signal).
Other than, in smaller acoustical spaces(most homes sadely), and then employing large bass traps there in, there's really not much more to consider in an average home audio set up! Maybe phase with a sub(s), etc, but not much else!
YOU SIMPLY CANNOT GO WRONG WITH WHAT i JUST SUMMED UP!!!
A solid foundation for flat and even(between speakers) frequency response from speakers/seats, proper speaker to speaker to listener set up(triangle, whatever), proper speaker toe-in/aim, proper phase(if applicable), proper acoustical considerations and/or treatments, and you cannot lose!
Other than bass management and EQing of difficult bass mode situations when applicable, there's not much more. Anything else is trial and error, and season to BEST RESTULTS GIVEN YOUR GEAR AND ROOM!
Good luck