Wemfan,
I just read the Stereophile review on the KEF LS50 speakers that Dbphd recommended. These look like something you should consider, very good review. You would need a pair of stands with these($100-150) and would probably need a new or used sub($800-1,000), too. Also, you'd need a 3-channel amp like the Emotiva for $799 and a matching KEF center channel for $300-400. At $1,500, the speakers look like a bargain but the whole setup would run between $3,500-3,700 plus the $1,200 for the Oppo 105. I'm not sure if you want to spend that much.
The Rlwainwright suggested Gallo Strada system looks very interesting but probably should be considered a hi-end alternative with a matching price of $3,100 for l/c/r and sub. You'd either need to wall mount the l+r small speakers or purchase the optional stands for $450/pr.
Another suggestion I would propose is the Golden Ears Triton Three speakers (http://www.goldenear.com/products/triton-series). These are $999 each but have a built in amplified sub in each speaker so no $1,000 sub should be needed. They are good looking floor stand speakers that might simplify your setup. You'd still need one of their matching center channels(the larger Supercenter XL for $799 or the smaller Supercenter X for $599)and a 3 channel amp like the Emotiva XPA-3 $799 on Amazon).
This I would also consider a hi-end system with matching price tag that would be a total of $3,396 -3,596, depending on the center channel chosen and also don't forget the extra $1,200 for the Oppo.
We're good at spending your money, aren't we?
As you can see, you have lots of options and we're only suggesting a few. You have so many options at your healthy budget that it may help you to visit a few retailers and get a listen.
Are you going to wall mount your 65" plasma? If yes, I think the wall mounted hdtv, with a shelf or stand below (containing the amp, Oppo and center channel) with a Triton Three flanking the tv on each side, would be an extremely good looking and sounding bedroom system. Of course, you could also substitute the KEFs or Gallos,too. You have a ton of options, my friend.
I wrote another reply yesterday that hasn't posted yet,
Tim