2 caveats w/new tubes, 1)be sure to turn bias screws back (counter clockwise) to minimum before you insert new tubes and turn on. 2) Although it was not a problem for me with my Cary amps, it is not unusual for a power tube loss to be accommodated by a blown out resistor in the bias curcuit. You should note this when you bias new tubes if it exists.
Hope that solves your problem.
Hope that solves your problem.