Different horses for different courses. Aside from the difference in power output, the tubes do differ in ways that make one or the other more ideal in a particular application. I generally find the 45 tube to have an ideal tonal balance and beautiful sound, without the 300B tendency to be overly lush and wooly sounding. The 2a3 is much leaner than the 45, but it sounds very fast and detailed and has a beautifully extended and airy top end.
In my system, both 45s and 2a3s work well. I am currently running 2a3s in parallel single-end configuration, but I also have a pushpull 45 amp that sounds nice.
In my system, both 45s and 2a3s work well. I am currently running 2a3s in parallel single-end configuration, but I also have a pushpull 45 amp that sounds nice.