Most subwoofers (I believe) have 2 input options - Hi level, and Low Level. Hi level inputs take signal from a Power amplifier, Low Level inputs take signal from the preamp. In the case of low level, it's always an RCA interconnect (and on the Rel they also have XLR Balanced). For high level inputs, you connect to your Power Amplifier's speaker output binding posts, and the oter end to the "high level input terminals on the Sub. For many subs, the high level input terminals are simply 5-way binding posts. The Rel uses a special connector - a Neutric Speakon connector.
My amp only has one set of binding posts (as most do) and I connect the Rel Cable to the same posts as my speakers. It's designed to be this way - and as I said, the amp hardly even knows it's there - electrically speaking. The other end of the Rel cable (is the subwoofer end) has a Neutric Speakon connector which plugs into the back of the Sub. Once connection is made, you need to set up the crossover and output level of the Sub. This is done by setting the controls on the Rel's amp panel and is described in detail in the Rel Manual. You can download the manual from the Rel website and read through their setup procedures - they're quite detailed and will also help explain the connections further.
hope that helps . . .