Help me build a nearfiield "desktop" audio system

In my office, I use a Fatman iTube ValveDock ( http://www.fat-man.co.uk/docs/product_07/iTube_ValveDock.shtml ) with a pair of inexpensive and amazing PSB Alpha B1 bookshelf speakers.

This mini-system is incrediby cool-looking and actually sounds pretty good beyond my expectations. Here's a bit of info on those semi-legendary bargain-priced boxes. Champagne nearfield listening on a beer budget!

Absolute Sound's 2009 Editors Choice Awards Alpha B1

Yet another “how does he do it?” loudspeaker from the prolific mind of Paul Barton. The new, more curvaceous Alpha combines mind-bending dynamics and rich mids in a speaker barely a foot tall. Even the midbass has a power and pitch definition rarely experienced in this modest price range. Only the nebulous soundstaging is less than excellent.

sounds like you're using your pc as a source, so you'll probably want a dac--consider something like the peachtree decco65 ($800), which is both integrated amp and dac + audioengine p4 speakers ($300ish) which are designed for at-or-near wall placement and are pretty impressive for their size. (peachtree also sells systems with their own speakers, which are well reviewed but unheard by me). if you want more oomph, audioengine also makes a sub for around $300. i'm sure you can spend more and get an even better system, but you might be very contended with the foiregoing.

May I recomend a single driver speaker for listening at the distance or at least a co-axial.

There's this http://centrance.com/products/audiophiledesktop/.
I have the DACmini and it's quite good but I have no personal experience with their integrated and speakers. I believe there is a trial period return policy.

With so much out there this is not going to be easy for you,
good luck!

All the best,
Nonoise