I doubt if you are ever using over .5 watts on either the Duos or Trios. In my experience as well as in a test done at the old VSAC in Silverdale WA, the 45 tube in its old American made form is clearly the best sounding output tube, if your speakers are sufficiently efficient. The old 2A3 single plates are close.
There are many variations in amps using tube output stages and certainly power supplies, parts quality, and other design features can alter the impact of the output tubes.
I have no experience with the 845 tube, but I have found great differences among 211s. Again the old RCAs clearly outperform the new Chinese tubes. So in reality we are talking not only about comparing 45s, 300Bs, and 845 but also NOS versus newer production.
The simple answer to the original posting is that the 8 watts from a 300B SET is quite sufficient for 107 db efficient speakers in the normal listening room.