Small signal tubes such as 12AX7's or 6922's are generally best left on 24/7. Quoting from the "TIPS & ADVICE" section of the owner's manual to my VAC Rennaisance 140/140 Mk. III tube amps:
"How long should tubes last? It has long been known in professional circles (and probably now forgotten) that a tube such as the 12AX7 will display BETTER performance characteristics after TWO YEARS of CONTINUAL operation than when it was new. In normal use it is not unusual for a low level tube to last 5 years or longer. Output tubes [i.e., power tubes used in tube power amps] are another story, as they are continuously providing significant amounts of current." (Emphasis original).
The expansion and contraction that small signal tubes undergo as gear heats up and cools down (as a result of being turned on and off) takes a toll over time. In addition, the voltage rush at turn-on is especially hard on small signal tubes. Tube gear with tube rectification is a lot easier on tubes at start-up, and some tube gear has a soft-start feature to soften the blow, while solid-state rectification is hard on them. In summary, while it is to a certain extent model-dependent, it's generally better, for both tube life and for sound quality, to leave tube preamps (and other gear that uses small signal tubes, like DAC's and tuners) on 24/7.
After a few years, the tubes should be replaced, as they do start to "lose their luster" (see Kevin Deal comments above), but they won't fail if used this way -- generally speaking, tubes left on 24/7 either fail within the first 250 hours or so from "infant mortality" or they last forever.
Output tubes cannot be left on 24/7 because they pass a lot of current and will wear out relatively quickly (not to mention wasting a lot of electricity and occasionally dying in spectacular fashion -- best not to leave them unattended).
"How long should tubes last? It has long been known in professional circles (and probably now forgotten) that a tube such as the 12AX7 will display BETTER performance characteristics after TWO YEARS of CONTINUAL operation than when it was new. In normal use it is not unusual for a low level tube to last 5 years or longer. Output tubes [i.e., power tubes used in tube power amps] are another story, as they are continuously providing significant amounts of current." (Emphasis original).
The expansion and contraction that small signal tubes undergo as gear heats up and cools down (as a result of being turned on and off) takes a toll over time. In addition, the voltage rush at turn-on is especially hard on small signal tubes. Tube gear with tube rectification is a lot easier on tubes at start-up, and some tube gear has a soft-start feature to soften the blow, while solid-state rectification is hard on them. In summary, while it is to a certain extent model-dependent, it's generally better, for both tube life and for sound quality, to leave tube preamps (and other gear that uses small signal tubes, like DAC's and tuners) on 24/7.
After a few years, the tubes should be replaced, as they do start to "lose their luster" (see Kevin Deal comments above), but they won't fail if used this way -- generally speaking, tubes left on 24/7 either fail within the first 250 hours or so from "infant mortality" or they last forever.
Output tubes cannot be left on 24/7 because they pass a lot of current and will wear out relatively quickly (not to mention wasting a lot of electricity and occasionally dying in spectacular fashion -- best not to leave them unattended).