Knownothing,
1. I let each fuse settle in for about 3-4 days. I agree with you, it takes about 70-100 hrs for the fuses to settle in. This was more apparent with the ceramic fuses for some reason. The glass fuses seemed to settle it much quicker. The Buss fuses needed more time to settle in than the HiFi-Tuning fuses.
2. I did try the directionality of the fuse, but only with the ceramic fuses. I did this after somebody mentioned it in this post. The HiFi-Tunning fuses seem to sound better when the arrow follows the direction of the signal. In my case, this difference was very subtle, so I would say it's inconclusive for now. The Buss fuses seemed to sound better with the UL logo at the end of the signal path, but again I can't tell for sure as the difference was not so noticeable. When going from one fuse to another, the sound difference was very apparent.
3. This makes a lot of sense to me since the circuits they plug in are totally different. As a matter of fact, HiFi-Tuning and Acme Audio fuses seem to work very well with Spectron amps, but I haven't try them in my amps yet. I'm very hesitant to use the HiFi-Tuning fuses in a power amp since they are not UL listed. I don't know the certification situation for the Acme Audio fuses.
I think the results may vary dramatically from system to system. I am extremely satisfied with the results I'm getting with the Buss fuses. In my particular case, the difference is comparable to switching signal cables. The fact that what works for me costs about $1.2 per fuse is the biggest bargain I've come across as an audiophile.