As Ralph has explained it to me (and I'm paraphrasing), the greater number of tubes in the MA-2 lowers the output impedance of the amp relative to an MA-1 or an M-60 (see Rwjp' post above). This lower output impedance allows the MA-2 to drive more easily a broader range of speakers (i.e., be less speaker sensitive) than many other OTLs.
One still needs to be cautious about the speaker's MINIMUM impedance (e.g., probably not less than the mid-3 ohms range) and still to seek speakers that have reasonably smooth impedance curves (no steep drops or spikes) without a lot of crazy phase shifts going on.
Ralph maintains the MA-2 can drive most speakers on the market, but there will always be some designs that simply won't be a good match. So, best to check.
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