This only remains theory because I cannot think of a manufacturer who builds the exact same amp as stereo, dual-mono in a single chassis, and monoblocks. Anytime a manufacturer goes to dual-mono, there will be more power compared to a single chassis. Hence, it is difficult to dissect the contribution of extra power from the benefit of channel separation.
The power supply is the most important part of a component. Being able to duplicate the power will result in a significant improvement. In addition, the ability to separate and truly isolate each chasis will provide benefit. The effect of internal and external vibrations is very real.
This concept holds true for many components. My DAC has separate chasis for each channel (40 lbs each), allowing for a very robust power supply. Having had the DAC power supply increased from one to two transformers per chasis, I can appreciate how important this can be. Likewise, top end preamps separate the power supply not because of interconnect, power, or weight issues, but because of the benefits of isolating different components which can interact in a single box.
Pass Labs has now introduced a lower powered mono-block (the X260.6). Although I have not heard it, I would probably bet that it would sound better than the higher powered, single-chassis X350.5 when used on appropriate speakers.