Well, do the speaker lead swap to eliminate the speaker. If the speakers are eliminated then put the leads back to the correct L & R connections and swap the amplifiers input IC's from the preamp now if the sound is still in the same speaker we have determined it to definitely be an amplifier issue and im gonna say a cap is acting up.
For now I would let the symptoms develop and become more pronounced because I may not rule out a tube completely as a failing tube has a way of playing havoc on other components such as caps,
Go through your tubes with a tester for starters but thats usually a long shot
What kind of power output tubes are we talking about?