I have amps that have been reported to run best in balanced mode, but I couldn't really hear a difference. These days my preamp (Herron VTSP-3A)does not have balanced outs so it is not even a possibility. With that said, I don't care, my preamp is the best one I have ever had and my system and I don't see not being able to run in balanced mode for my amp as a big deal as it sounds darn good to my ears the way things are.