For an excellent tube set-up a Leben Integrated tube amp would be a good start, although there are other fine integrated tube amps. Along with a relatively easy to drive speaker system, such as Harbeth, Devore, Vaughn (direct-buy), Coincident Technologies (direct buy), and you would have a killer system. If you get a good cd or sacd/cd player, or even a universal player would help, as would a good turntable and cartridge, if you are interested in getting into vinyl.
Of course, everything depends on your budget, so in order to give you better direction, that information would be necessary.
Of course, everything depends on your budget, so in order to give you better direction, that information would be necessary.