I assume you have been reading reviews of the 452 as have I. I have not heard it, but it seems that it delivers a sound to compete with the Parasound Halo JC-1, Plinius, PASS LABS and has departed from the McIntosh house sound.
An excerpt from a online review:
"I believe McIntosh has quietly revoiced this amp, and I would suspect the MC601 as well. I can't say whether it is the new ThermalTrak output transistors that have altered the sonic signature, or if the audio circuits have been intentionally redesigned to voice the amp differently. What I am experiencing is a sound that seems dynamically quicker, more analytical, particularly in the upper midrange frequencies. There is a sharper clarity to strings, grouped voices, drum snaps, and cymbals. Piano comes across slightly crisper in tone in the upper octaves, yet not in an objectionable manner."
But you'll still need to hear it for yourself.
An excerpt from a online review:
"I believe McIntosh has quietly revoiced this amp, and I would suspect the MC601 as well. I can't say whether it is the new ThermalTrak output transistors that have altered the sonic signature, or if the audio circuits have been intentionally redesigned to voice the amp differently. What I am experiencing is a sound that seems dynamically quicker, more analytical, particularly in the upper midrange frequencies. There is a sharper clarity to strings, grouped voices, drum snaps, and cymbals. Piano comes across slightly crisper in tone in the upper octaves, yet not in an objectionable manner."
But you'll still need to hear it for yourself.