Recommendations for Amp/speaker combo for $10,000

Are you considering anything specific yet? In amps, pre amps, or speakers? Your question is so vague (altho it's good that you listed your Room size & music preference), you could get dozens of answers, many of which could be good.

I'd focus on speakers first probably--unless you're totally decided on a tube amp--then you could pick the amp & get tube friendly speakers.....

Not knowing much about your room or tastes, if I were about to spend 10k it would be something like,

Ayre integrated with aerial 7t's
Or, Ayre separates with Nola contenders, vandy's, possibly aerial 7b (I love mine but given how long they've been around you may not be comfortable with the likely age of the speakers you'd be buying).

If I could stretch a bit I'd do 7t or 9's with Ayre separates.

Try the Bob Carver Cherry 180 (200 watt) tube mono blocks with built in volume control and Magnaplanar 1.7 or Reference 3A MM DeCapo. Transparency, truth of timbre, incredible soundstage/imaging, dynamics, life-like sound. You won't get ultimate bass extension with these speakers though. You'll need subwoofer for that.

Tannoy DC10T floorstanding speakers with 300B SET amp, e.g., Wavelength Cardinal. Recommend you buy the speakers new or demo, and look for a used pair of Cardinal X2 monoblocks.

I recommend the Philharmonic 2s with a Mackintosh 275 amp. The Phils are the most transparent speaker that I have heard. They could really convince me that the instruments are in front of me on stage. The Philharmonic 3 has a bit more bass but is less efficient which would be a factor in choosing a tube amp. With the Philharmonic 3s you would want to consider getting two tube amps in monoblock form used.

Bob