I think you will still have issues with frequency response variations due to impedance variations, if you run a large solid state amp. If you run a speaker with a nominal 8 ohm impedance that rises to 16 Ohms, and drops to 4 ohms at times, I'm guessing that may cause up to a 6 db variation in levels at different frequencies, with an amp that doubles its power every time the impedance is halved.
For example, if an 8 Ohm speaker rises to 16 ohms at roughly 12 kHz, the amp (large solid state) will only put out half of the power at the time, causing about a 3 db drop in sound level, at that frequency and time. If the load drops to 4 ohms at 1 kHz, the power will double at that time, giving it roughly a 3 db level increase during that drop to 4 ohms, due to the amp doubling its power at that moment. That's why I'm guessing up to a 6 db variation in this case, if the amp doubles its power that way. Even more of a change in frequency response variations yet, if the speaker impedance varies more than what I just mentioned.
So a potent solid state amp that doubles its power when the impedance is halved, may be less neutral sounding then an amp that can't double its power. I can see this happening. So basically, its still about how each amp reacts to certain loads demanded by various speakers, solid state, or tube.