B&W matrix 801 s2 still a relavant speaker.

What a strange question. If it sounds good to you, then it's worth keeping, unless you can afford something that you like more. I don't think what the rest of "today's world" thinks matters.

I am running 1972 JBL 4350A speakers and I think they are pretty relevant even today.....

I have a pair of B&W 801 Series 3's and they have caused me to stopped me chasing my tail, when it comes to speakers. They replaced newer Thiel CS6's and I have never look back. If your are happy with your system, just listen, that's what it all about.

They're definitely classics. I think it's the biggest selling high end speaker of all time? Whether they're relevant is entirely up to you.

Yes it is.