JBL is a 4340 better than a 250ti?

Do you mean a 4430? That's a tough one to answer. I have owned a pair of 4430s and when set up properly they are unbelievable. I have listened to 250ti's at a friends and thought they sounded great. Never heard the 2 side by side in the same room.

the 4430 is really a studio product. the 250 may be better for the living room.

Different animals. What type of music do you 'primarily' listen to?

I was referring to a 4340, very similar to a 4341, 4350..