More info is needed.
What make and model for the amp? How old is it? Has it been serviced lately? How many hours are on the tubes?
Does the hiss occur when only the amp is on and no sources are connected?
Same with the speakers. If the speakers are particularly efficient you may notice hiss that a less efficient set of speakers would not reveal.
In short, the more information provided, the better the answer.
What make and model for the amp? How old is it? Has it been serviced lately? How many hours are on the tubes?
Does the hiss occur when only the amp is on and no sources are connected?
Same with the speakers. If the speakers are particularly efficient you may notice hiss that a less efficient set of speakers would not reveal.
In short, the more information provided, the better the answer.