If the gain of your pre-amp is too high you would not have very much use of the VC. Assuming a normal amp input sensitivity, you would probably be restricted to volume control use below 9 o'clock where some VCs may have balance issues and, if stepped, the incremental increases between steps is too high.
For example some pre's have 3db (or more) steps at the bottom of the scale, but when you get up to say 10 to 2 o'clock (the former being probably normal for average systems and the latter for really inefficent systems) the gradient of steps may be reduced to as little as .5bd and gives you a lot of flexibility for fine tuning.
This is sort of generic information, but I hope it helps a bit.