Yes. Same changes that you hear on DACs and CD players, etc. I put a Taipan Helix on it and the sound was more punchy, dynamic and a bit smoother. I put a Taipan Helix Vx on it and the dynamics were lessened a bit, but the higher frequency response was cleaned up more to my liking(i.e. smothered).
For whatever reason, I can't run it through my Hydra. Everytime I try, it makes the upper frequencies far too strident (like having all silver cabling). My amp/dac are run off another Hydra connected to another outlet.
I tried a Mamba V2 and the Taipan Helix Vx on it recently and went with the Taipan Vx because it did a better job of "smothering" the high frequencies and dulling things a bit more (which balanced well with the rest of my system being too forward/detailed). I don't think I could stand the Taipan Vx on a DAC or CD player, but it does fantastic on a computer.