Speaking for myself only, chicken tastes as good today as it did when I was a youngster. I fully comprehend your analogy, but feel that it doesn't fit in this situation.
We've all heard what different cabling can do for a system, (some of us have even the sonic effects of changing out an input wire on an amp). This said, it makes sense that internal direct wiring within the circuit itself would have similar effects. It may be difficult to have a wire trace with as much actual area as a 12 or 14 gauge wire, (which may be the optimum size for the circuit design). We haven't even gotten into different grades of copper used in PCB's as compared to the extremely wide variety of wire available for use.
I believe that there are some great reasons for PCB's, sonics not neccessarily one of them. We all have PCB's in our systems, so I'm not saying that good sound isn't possible with PCB's, just that they present compromises.
To state that point to point is amatuerish, DIY, or throwback is off base and may not be the primary reason for utilizing this build design.