No harm per se but umbilical cord with male - female connectors can only be plugged in one direction. Now my mono amps with external power supply came with umbilical cords with same male speakon connectors on both ends, like the one below with no directionality marked on the wire.
https://www.neutrik.com/en/product/nl8fcSo when I asked the manufacturer, he said it should not make any difference which way I plug the cords. I heard no audible differences when I reversed the cord in other direction.
I have yet to see a professionally made power cord with male AC and female IEC plugs marked with directionality.
Our resident directionality guru @geoffkait may disagree with my assessment 😊