Easiest if you can get an installer to integrate them. Acoustics, EQ and placement all matter. A pro can do it in 1/50th the time.
Next most easy is if you find a sub with a good sounding auto-EQ. I can’t hear the difference between super awesome 500 tonne subs and merely very good subs, but I CAN hear the difference in the EQ settings. So it’s very worthwhile asking other owners for their experiences. If you JUST do EQ it won’t be nearly as good as EQ plus room treatment.
Hardest is getting the room right, measuring, placing it yourself and creating your own EQ curves.
Equally difficult is getting 2 subs right.
Additional resources:
http://ethanwiner.com/basstrap_myths.htm
http://www.roomeqwizard.com/
www.GIKAcoustics.com
www.data-bass.com
Best,
Erik