There are differences that are more easily detected, as stated above, the more resolving your system is. In your system u have to figure out which general amplifier type u like better. Complicating matters is that within an amplifier type there will be discernable differences in sound signature. I find that I mostly gravitate toward high powered hybrid and solid state amps driven by a tube preamp. I have a modest powered strong performing class d amp that's also a honey. You just have to listen, experiment and experiment more. You can listen to reviewers, at least some of them. However, I have had gear that once listened to, I could not get my arms around what had been written in a respectable Audio mag. I have though found an alignment with Terry London's listening preferences- not completely but mostly.