Interesting situation, Zaikesman.
It sounds as if you're going to do a combination of nearfield and across-the-room listening?
I just got the Klipsch ProMedia 2.1 sat/sub combo and am quite impressed with the naturalness of the sound relative to other computer speaker systems and the strain-free volume at which they play. I run my speakers off a Macintosh Quad-core G5 using iTunes and from the analog outs, and am surprised that I'm able to get nice sound from a cheap [the speakers only] set up like this. The iTunes equalizer allows me to adjust the sound to my liking even more.
You can get the ProMedias at Amazon.com for about $110. Build quality may be an issue with them though, as I had to get a replcement set because one of the channels didn't output sond. The second set suffers from a loose 3mm jack on the back of one of the satellites, but I got it to work.
Before the Klipsch I'd been using a Swan sat/sub combo that just recently crapped out. The Swans didn't have the exagerated treble and bass so many desk top computer speaker systems have, but they also had anemic bass and wouldn't play very loud. I didn't go with the Swan M200s because they're about 13" tall, but I should note that these are the Swans most people speak so highly of.
It's funny that people are talking about NHTs for your set up as I have an extra set of SuperZeros at home and had considered doing exactly the same thing. I've been thinking of bringing my Audio Mirror DAC, Blue Circle BC22 and NHTs to work and run them off the toslink outs of my computer. If I did that I'd probably also bring my 29" tall steel shot filled Lovan stands in and set them up traditionally, not on my desk.
I had also considered using little speakers with a small tube amp too.