There are major differences in tubes, both in 12AU7 and 12AX7 types. In both cases my favorite is Telefunken, especially in the 12AX7 type. I think they build the best 12AX7 ever made.
Will different tubes and brands make any difference in sound?
That depends entirely on your system and set up. Your system is not posted here at Audiogon, so I don't know your other components or room set up.
Assuming the rest is equal to your VTL 2.5, I would say yes, premium tubes will be an audible improvement in your system.
Is it worth the investment? That is another matter, especially when discussing Telefunken, which are expensive.
Will different tubes and brands make any difference in sound?
That depends entirely on your system and set up. Your system is not posted here at Audiogon, so I don't know your other components or room set up.
Assuming the rest is equal to your VTL 2.5, I would say yes, premium tubes will be an audible improvement in your system.
Is it worth the investment? That is another matter, especially when discussing Telefunken, which are expensive.